The reason is that all Open World Activities will be marked automatically on your map after finishing the story, and several side storylines are gated behind story progression. After the story you will have access to all the side content. Your primary focus should be the story first. Step 1: Finish the Story (Any Difficulty) Some trophies can become very grindy if you don’t focus on them from the beginning, read Step 1 of the Roadmap carefully for those. The final mission can be replayed as often as you want for the different Endings. After the story you will be put back before the Point of No Return (before final Mission) and can continue doing any side activities you have left. The rest of your story choices don’t impact any trophies or endings (only saving Takemura).
Also keep 17 unspent Attribute Points on a Manual Save so that you can get all attribute-related trophies in one playthrough. You’ll also want to be careful to not fail the Side Quests of Panam / Rogue / Judy Alvarez / River Ward / Kerry Eurodyne because they are needed for trophies. It doesn’t matter what starting lifepath you choose, so go with whatever you like. The main thing to watch out for is to keep a Manual Save from the start of Main Mission “ Search and Destroy” (near end of story) because you must save Takemura there for an Ending trophy. There are no difficulty-related trophies. Everything can be done on Easy Difficulty. Welcome to the Cyberpunk 2077 Trophy Guide! The trophies in CP77 can be divided into the following categories: Story, Endings, certain Side Questlines, Miscellaneous / Combat, Collectibles, Side Activities.
From here you can also replay the final missions for the different endings.
This puts you back before the final missions and you can continue in free roam and finish up any Gigs, Side Jobs and NCPD scanner events you have left. After finishing the story when the credits are done rolling, choose “Sure, Just One More Gig” to be put back before the Point of No Return.